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| PubMed | |
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Article by XU Li-xian |
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Article by LUO Dan |
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�Ͼ�ҽ�ƴ�ѧ��һ����ҽԺƤ����, 210029
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The Mechanism of Cutaneous Photoprotection from Ultraviolet by (-)-epigallocatechin-3-gallate
Department of Dermatology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China
Department of Dermatology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China
Epidemiologic studies have demonstrated that some components of green tea have an inhibitory effect on carcinogenesis, which attributes to the biologic activities of polyphenol in the tea. It is found that a polyphenolic constituent, (-)-epigallocatechin-3-gallate (EGCG), is the major and most effective photoprotective agent in green tea. In the recent years much progress has been made in the study of photoprotective mechanisms of EGCG in skin.
[2] Katiyar SK,Mukhtar H.Green tea polyphenol (-)-epigallocatechin-3-gallate treatment to mouse skin prevents UVB-induced infiltration of leukocytes,depletion of antigen-presenting cells,and oxidative stress.J Leukoc Biol,2001,69:719-726.
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[6] Katiyar SK,Bergamo BM,Vyalil PK,et al.Green tea polyphenols:DNA photodamage and photoimmunology.J Photochem Photobiol B,2001,65:109-114.
[7] Katiyar SK,Challa A,McCormick TS,et al.Prevention of UVB-induced immunosuppression in mice by the green tea polyphenol (-)-epigallocatechin-3-gallate may be associated with alterations in IL-10 and IL-12 production.Carcinogenesis,1999,20:2117-2124.
[8] Katiyar SK.Skin photoprotection by green tea:antioxidant and immunomodulatory effects.Curr Drug Targets Immune Endocr Metabol Disord,2003,3:234-242.
[9] Goukassian DA,Helms E,van Steeg H,et al.Topical DNA oligonucleotide therapy reduces UV-induced mutations and photocarcinogenesis in hairless mice.Proc Natl Acad Sci U S A,2004,101:3933-3938.
[10] Mittal A,Piyathilake C,Hara Y,et al.Exceptionally high protection of photocarcinogenesis by topical application of (-)-epigallocate-chin-3-gallate in hydrophilic cream in SKH-1 hairless mousemodel:relationship to inhibition of UVB-induced global DNA hy-pomethylation.Neoplasia,2003,5:555-565.
[11] Morley N,Clifford T,Salter L,et al.The green tea polyphenol (-)-epigallocatechin gallate and green tea can protect human cellularDNA from ultraviolet and visible radiation-induced damage.Photo-dermatol Photoimmunol Photomed,2005,21:15-22.
[12] Chen W,Dong Z,Valcic S,et al.Inhibition of ultraviolet B-inducedc-fos gene expression and p38 mitogen-activated protein kinase ac-tivation by (-)-epigallocatechin gallate in a human keratinocyte cellline.Mol Carcinog,1999,24:79-84.
[13] Kim J,Hwang JS,Cho YK,et al.Protective effects of (-)-epigallo-catechin-3-gallate on UVA-and UVB-induced skin damage.SkinPharmacol Appl Skin Physiol,2001,14:11-19.
[14] Afaq F,Adhami VM,Ahmad N,et al.Inhibition of ultraviolet B-mediated activation of nuclear factor kappaB in normal human epi-dermal keratinocytes by green tea Constituent (-)-epigallocatechin-3-gallate.Oncogene,2003,22:1035-1044.
[15] Einspahr JG,Bowden GT,Alberts DS.Skin cancer chemopreven-tion:strategies to save our skin.Recent Results Cancer Res,2003,163:151-164.
[16] Lu YP,Lou YR,Xie JG,et al.Topical applications of caffeine or(-)-epigallocatechin gallate (EGCG) inhibit carcinogenesis and se-lectively increase apoptosis in UYB-induced skin tumors in mice.Proc Natl Acad Sci U S A,2002,99:12455-12560.
[17] Lin JK,Liang YC.Cancer chemoprevention by tea polyphenols.Proc Natl Sci Counc Repub China B,2000,24:1-13.
[18] Katiyar SK,Elmets CA.Green tea polyphenolic antioxidants andskin photoprotection (Review).Int J Oncol,2001,18:1307-1313.