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[2] Steinhoff M, Corvera CU, Thoma MS, et al. Proteinase-activated receptor-2 in human skin:tissue distribution and activation of keratinocytes by mast cell tryptase. Exp Dermatol, 1999, 8:282-294.
[3] Ossovskaya VS, Bunnett NW. Protease-activated receptors:contribution to physiology and disease. Physiol Rev, 2004, 84:579-621.
[4] Nguyen TD. Proteinase activated receptor 2:a protean effector comes 9f age. Gastroenterology, 2004, 126:1907-1909.
[5] DeFea KA, Zalevsky J, Thoma MS, et al. beta-arrestin-dependent endocytosis of proteinase-activated receptor 2 is required for intracellular targeting of activated ERK 1/2. J Cell Biol, 2000, 148:1267-1281.
[6] Ridley AJ. Rho family proteins:coordinating cell responses. Trends Cell Biol, 2001, 11:471-477.
[7] Seiberg M, Paine C, Sharlow E, et al. The protease-activated receptor 2 regulates pigmentation via keratinocyte-melanocyte interactions. Exp Cell Res, 2000, 254:25-32.
[8] Virador VM, Muller J, Wu X, et al. Influence of alpha-melanocytestimulating hormone and ultraviolet radiation on the transfer of melanosomes to keratinocytes. FASEB J, 2002, 16:105-107.
[9] Babiarz-Magee L, Chen N, Seiberg M, et al. The expression and activation of protease-activated receptor-2 correlate with skin color.Pigment Cell Res, 2004, 17:241-251.
[10] O'Brien PJ, Prevost N, Molino M,et al. Thrombin responses in human endothelial cells. Contributions from receptors other than PAR1 include the transactivation of PAR2 by thrombin-cleaved PAR1. J Biol Chem, 2000, 275:13502-13509.
[11] Meyer-Hoffert U, Rogalski C, Seifert S, et al. Trypsin induces epidermal proliferation and inflammation in murine skin. Exp Dermatol, 2004, 13:234-241.
[12] Scott G, Leopardi S, Parker L, et al. The proteinase-activated receptor-2 mediates phagocytosis in a Rho-dependent manner in human keratinocytes. J Invest Dermatol, 2003, 121:529-541.
[13] Boissy RE. Melanosome transfer to and translocation in the keratinocyte. Exp Dermatol, 2003, 12(Suppl 2):5-12.
[14] Paine C, Sharlow E, Liebel F,et al. An alternative approach to depigmentation by soybean extracts via inhibition of the PAR-2 pathway. J Invest Dermatol, 2001, 116:587-595.
[15] Scott G, Deng A, Rodriguez-Burford C, et al. Protease-activated receptor 2, a receptor involved in melanosome transfer, is upregulated in human skin by ultraviolet irradiation. J Invest Dermatol,2001, 117:1412-1420.
[16] Hou L, Kapas S, Cruchley AT, et al. Immunolocalization of protease-activated receptor-2 in skin:receptor activation stimulates interleukin-8 secretion by keratinocytes in vitro. Immunology,1998, 94:356-362.
[17] Asokananthan N, Graham PT, Fink J,et al. Activation of proteaseactivated receptor (PAR)-1, PAR-2, and PAR-4 stimulates IL-6,IL-8, and prostaglandin E2 release from human respiratory epithelial cells. J Immunol, 2002, 168:3577-3585.
[18] Scott G, Leopardi S, Printup S, et al. Proteinase-activated receptor-2 stimulates prostaglandin production in keratinocytes:analysis of prostaglandin receptors on human melanocytes and effects of PGE2and PGF2alpha on melanocyte dendricity. J Invest Dermatol, 2004,122:1214-1224.
[19] Baxter LL, Hou L, Loftus SK, et al. Spotlight on spotted mice:a review of white spotting mouse mutants and associated human pigmentation disorders. Pigment Cell Res, 2004, 17:215-224.