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Abstract:

Keywords:
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[1] Lu D, Willard D, Patel IR, et al. Agouti protein is an antagonist of the melanocyte-stimulating-hormone receptor. Nature, 1994, 371:799-802.
[2] Kwon HY, Bultman SJ, Loffler C, et al. Molecular structure and chromosomal mapping of the human homolog of the agouti gene. Proc Natl Acad Sci U S A, 1994, 91:9760-9764.
[3] Voisey J, van Daal A. Agouti: from mouse to man, from skin to fat.Pigment Cell Res, 2002, 15:10-18.
[4] Eberle AN, Bodi J, Orosz G, et al. Antagonist and agonist activities of the mouse agouti protein fragment (91-131 ) at the melanocortin-1 receptor. J Recept Signal Transduct Res, 2001, 21:25-45.
[5] Miller MW, Duhl DM, Vrieling H, et al. Cloning of the mouse agouti gene predicts a secreted protein ubiquitously expressed in mice carrying the lethal yellow mutation. Genes Dev, 1993, 7:454-467.
[6] Vrieling H, Duhl DM, Millar SE, et al. Differences in dorsal and ventral pigmentation result from regional expression of the mouse agouti gene. Proc Natl Acad Sci U S A, 1994, 91:5667-5671.
[7] Millar SE, Miller MW, Stevens ME, et al. Expression and transgenic studies of the mouse agouti gene provide insight into the mechanisms by which mammalian coat color patterns are generated. Development,1995, 121:3223-3232.
[8] Matsunaga N, Virador V, Santis C, et al. In situ localization of agouti signal protein in murine skin using immunohistochemistry with an ASP-specific antibody. Biochem Biophys Res Commun, 2000, 270:176-182.
[9] Voisey J, Box NF, van Daal A. A polymorphism study of the human Agouti gene and its association with MC1R. Pigment Cell Res, 2001,14:264-267.
[10] Kanetsky PA, Swoyer J, Panossian S, et al. A polymorphism in the agouti signaling protein gene is associated with human pigmentation.Am J Hum Genet, 2002, 70:770-775.
[11] Willard DH, Bodnar W, Harris C, et al. Agouti structure and function: characterization of a potent alpha-melanocyte stimulating hormone receptor antagonist. Biochemistry, 1995, 34:12341-12346.
[12] Perry WL, Nakamura T, Swing DA, et al. Coupled site-directed mutagenesis/transgenesis identifies important functional domains of the mouse agouti protein. Genetics, 1996, 144:255-264.
[13] Kiefer LL, Ittoop OR, Bunce K, et al. Mutations in the carboxyl terminus of the agouti protein decrease agouti inhibition of ligand binding to the melanocortin receptors. Biochemistry, 1997, 36:2084-2090.
[14] Kobayashi T, Vieira WD, Potterf B, et al. Modulation of melanogenic protein expression during the switch from eu-to pheomelanogenesis. J Cell Sci, 1995, 108:2301-2309.
[15] Furumura M, Sakai C, Potterf SB, et al. Characterization of genes modulated during pheomelanogenesis using differential display. Proc Natl Acad Sci U S A, 1998, 95:7374-7378.
[16] Furumura M, Potterf SB, Toyofuku K, et al. Involvement of ITF2 in the transcriptional regulation of melanogenic genes. J Biol Chem,2001, 276:28147-28154.
[17] Suzuki I, Tada A, Ollmann MM,et al. Agouti signaling protein inhibits melanogenesis and the response of human melanocytes to alphamelanotropin. J Invest Dermatol, 1997, 108:838-842.
[18] Ollmann MM, Lamoreux ML, Wilson BD, et al. Interaction of Agouti protein with the melanocortin 1 receptor in vitro and in vivo. Genes Dev, 1998, 12:316-330.
[19] Voisey J, Kelly G, Van Daal A. Agouti signal protein regulation in human melanoma cells. Pigment Cell Res, 2003, 16:65-71.
[20] Duke-Cohan JS, Morimoto C, Rocker JA, et al. Serum high molecular weight dipeptidyl peptidase �� (CD26) is similar to a novel antigen DPPT-L released from activated T cells. J Immunol, 1996, 156:1714-1721.
[21] Duke-Cohan JS, Kim JH, Azouz A. Attractin: cautionary tales for therapeutic intervention in molecules with pleiotropic functionality. J Environ Pathol Toxicol Oncol, 2004,23:1-11.
[22] Gunn TM, Miller KA, He L, et al. The mouse mahogany locus encodes a transmembrane form of human attractin. Nature, 1999, 398:152-156.
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