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��Ƥ��Բ�ѧ��־ 2005, 31(4) 232-234 DOI: ISSN: 2096-5540 CN: 32-1880/R

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1. ��ϴ�ѧ��Ŷ�ҽԺƤ��, ��ɳ410011;
2. ��Ъ��ѧҽѧ�о��

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2. ��Ъ��ѧҽѧ�о��

Abstract:

Keywords:

�ո�� 2004-08-17 �޻�� ��淢��

DOI:

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[1] Deng C, Kaplan MJ, Yang J, et al. Decreased Ras-mitogen-activated protein kinase signaling may cause DNA hypomethylation in T lymphocytes from lupus patients. Arthritis Rheum, 2001,44:397-407.
[2] Lu Q, Kaplan M, Ray D, et al. Demethylation of ITGAL (CD11a)regulatory sequences in systemic lupus erythematosus. Arthritis Rheum, 2002, 46:1282-1291.
[3] Yung R, Powers D, Johnson K, et al. Mechanisms of drug-induced lupus. ��. T cells overexpressing lymphocyte function-associated antigen 1 become autoreactive and cause a lupuslike disease in syngeneic mice. J Clin Invest, 1996, 97:2866-2871.
[4] Deng C, Lu Q, Zhang Z,et al. Hydralazine may induce autoimmunity by inhibiting extracellular signal-regulated kinase pathway signaling.Arthritis Rheum, 2003, 48:746-756.
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[11] Clark SJ, Harrison J, Paul CL, et al. High sensitivity mapping of methylated cytosines.Nucleic Acids Res, 1994, 22:2990-2997.
[12] Kaplan MJ, Deng C, Yang J, et al. DNA methylation in the regulation of T cell LFA-1 expression. Immunol Invest, 2000, 29:411-425.
[13] Takeuchi T, Amano K, Sekine H, et al. Upregulated expression and function of integrin adhesive receptors in systemic lupus erythematosus patients with vasculitis. J Clin Invest, 1993, 92:3008-3016.
[14] Lu Q, Ray D, Gutsch D, et al. Effect of DNA methylation and chromatin structure on ITGAL expression. Blood, 2002, 99:4503-4508.
[15] Nakamura T, Ebihara I, Tomino Y, et al. Perforin mRNA expression in the inflamed tissues of NZB/W F1 lupus mice decreases with methylprednisolone treatment. Am J Pathol, 1991, 139:731-736.
[16] Lens SM, Tesselaar K, van Oers MH, et al. Control of lymphocyte function through CD27-CD70 interactions. Semin Immunol, 1998,10:491-499.
[17] Oelke K, Lu Q, Richardson D, et al. Overexpression of CD70 and overstimulation of IgG synthesis by lupus T cells and T cells treated with DNA methylation inhibitors. Arthritis Rheum, 2004, 50:1850-1860.
[18] Kobata T, Jacquot S, Kozlowski S, et al. CD27-CD70 interactions regulate B-cell activation by T cells. Proc Natl Acad Sci U S A,1995, 92:11249-11253.
[19] Deng C, Kaplan M J, Yang J, et al. Decreased Ras-mitogen-activated protein kinase signaling may cause DNA hypomethylation in T lymphocytes from lupus patients. Arthritis Rheum, 2001,44:397-407.

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