[an error occurred while processing this directive] | ����Ƥ���Բ�ѧ��־ 2005, 31(4) 199-201 DOI: ISSN: 2096-5540 CN: 32-1880/R | ||||||||||||||||||||||||||||||||||||||||||||||||||
����Ŀ¼ | ����Ŀ¼ | ������� | ������ [��ӡ��ҳ] [�ر�] | |||||||||||||||||||||||||||||||||||||||||||||||||||
���� |
| ||||||||||||||||||||||||||||||||||||||||||||||||||
��Ƥ�ʼ��������о���չ | |||||||||||||||||||||||||||||||||||||||||||||||||||
������, �����, ��־ǿ | |||||||||||||||||||||||||||||||||||||||||||||||||||
�й�ҽѧ��ѧԺ���й�Э��ҽ�ƴ�ѧƤ�����о���, �Ͼ�210042 | |||||||||||||||||||||||||||||||||||||||||||||||||||
ժҪ��
��Ƥ�ʼ����������������������,��Ƥ�ʼ�����Ҫ����Ƥ�ʼ�����������,����������ҩ����,��Ƥ�ʼ�����������ܶȼ���������Ƥ�ʼ��ص���Ч�������,��Ƥ�ʼ�������²�����Ƥ�ʼ��ؽ�ϡ����������о�����,��Ƥ�ʼ�������¶���Ƥ�ʼ���������Ĺ����������á�Ϊ��,����Ƥ�ʼ�������ҩ�����õķ�������ѧ���ơ���Ƥ�ʼ��������쳣����Ƥ�ʼ��ع��ܵ�Ӱ�켰ϸ�����ӡ�ת¼����ӵȶ���Ƥ�ʼ������幦�ܵĵ������ý��������� | |||||||||||||||||||||||||||||||||||||||||||||||||||
�ؼ����� ����,��Ƥ�ʼ��� ϸ������ ת¼����� | |||||||||||||||||||||||||||||||||||||||||||||||||||
Abstract: | |||||||||||||||||||||||||||||||||||||||||||||||||||
Keywords: | |||||||||||||||||||||||||||||||||||||||||||||||||||
�ո����� 2004-09-23 ������ ����淢������ | |||||||||||||||||||||||||||||||||||||||||||||||||||
DOI: | |||||||||||||||||||||||||||||||||||||||||||||||||||
������Ŀ: | |||||||||||||||||||||||||||||||||||||||||||||||||||
ͨѶ����: | |||||||||||||||||||||||||||||||||||||||||||||||||||
�����: | |||||||||||||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||||||||
�ο����ף� | |||||||||||||||||||||||||||||||||||||||||||||||||||
[1] Oakley RH, Jewell CM, Yudt MR, et al. The dominant negative activity of the human glucocorticoid receptor beta isoform. Specificity and mechanisms of action. J Biol Chem, 1999, 274:27857-27866. [2] Buttgereit F, Wehling M, Burmester GR. A new hypothesis of modular glucocorticoid actions: steroid treatment of rheumatic diseases revisited. Arthritis Rheum, 1998,41:761-767. [3] Cho YJ, Lee KE. Decreased glucocorticoid binding affinity to glucocorticoid receptor is important in the poor response to steroid therapy of older-aged patients with severe bronchial asthma. Allergy Asthma Proc, 2003, 24:353-358. [4] Pujols L, Xaubet A, Ramirez J, et al. Expression of glucocorticoid receptors alpha and beta in steroid sensitive and steroid insensitive interstitial lung diseases. Thorax, 2004, 59:687-693. [5] Sousa AR, Lane SJ, Cidlowski JA,et al. Glucocorticoid resistance in asthma is associated with elevated in vivo expression of the glucocorticoid receptor beta-isoform. J Allergy Clin Immunol, 2000, 105:943-950. [6] Honda M, Orii F, Ayabe T,et al. Expression of glucocorticoid receptor beta in lymphocytes of patients with glucocorticoid-resistant ulcerative colitis. Gastroenterology, 2000, 118:859-866. [7] Chikanza IC. Mechanisms of corticosteroid resistance in rheumatoid arthritis: a putative role for the corticosteroid receptor beta isoform.Ann N Y Acad Sci, 2002, 966:39-48. [8] Gagliardo R, Chanez P, Vignola AM, et al. Glucocorticoid receptor alpha and beta in glucocorticoid dependent asthma. Am J Respir Crit Care Med, 2000, 162:7-13. [9] Kam JC, Szefler S J, Surs W, et al. Combination IL-2 and IL-4 reduces glucocorticoid receptor-binding affinity and T cell response to glucocorticoids. J Immunol, 1993, 151:3460-3466. [10] Sher ER, Leung DY, Surs W, et al. Steroid-resistant asthma. Cellular mechanisms contributing to inadequate response to glucocorticoid therapy. J Clin Invest, 1994, 93:33-39. [11] Spahn JD, Szefler SJ, Surs W, et al. A novel action of IL-13: induction of diminished monocyte glucocorticoid receptor-binding affinity. J Immunol, 1996, 157:2654-2659. [12] Webster JC, Oakley RH, Jewell CM, et al. Proinflammatory cytokines regulate human glucocorticoid receptor gene expression and lead to the accumulation of the dominant negative beta isoform: a mechanism for the generation of glucocorticoid resistance. Proc Natl Acad Sci U S A,2001, 98:6865-6870. [13] McKay LI, Cidlowski JA. Cross-talk between nuclear factor factor-kappa B and the steroid hormone receptors: mechanisms of mutual antagonism. Mol Endocrinol, 1998,12:45-56. [14] Adcock IM, Lane SJ, Brown CR, et al. Abnormal glucocorticoid receptor-activator protein 1 interaction in steroid-resistant asthma. J Exp Med, 1995, 182:1951-1958. |
|||||||||||||||||||||||||||||||||||||||||||||||||||
������������� | |||||||||||||||||||||||||||||||||||||||||||||||||||
�������� (��ע��:��վʵ�������Ը�, �벻Ҫ������ѧ���ص�����!�������ݲ�����վ�۵�.) | |||||||||||||||||||||||||||||||||||||||||||||||||||
Copyright 2008 by ����Ƥ���Բ�ѧ��־ |