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ɳ����ԭ��������Ԥ��������ɳ����ԭ���Ⱦ�����Ч�Ĵ�ʩ֮һ.ɳ����ԭ���������ǵ�λ���硢��ͻ״ϸ�������DNA�����.���������о�֤��DNA����������DZ����ɳ����ԭ������.�������Ҫ��Ĥ����DNA�����������߷�Ӧ��,������Ҫ��Ĥ�������ߴ̼�������ǿ���Ŵ�����ЧӦ�����߷���,ȡ���˽Ϻõ�Ч��.
[2] Smith JS, Munoz N, Herrero R, et al. Evidence for Chlamydia trachomatis as a human papillomavirus cofactor in the etiology of invasive cervical cancer in Brazil and the Philippines. J Infect Dis, 2002, 185(3):324-331.
[3] Pal S, Thoodor I, Peterson EM, et al. Immunization with an acellular vaccine consisting of the outer membrane complex of Chlamydia trachomatis induces protection against a genital challenge. Infect Immun,1997, 65(8):3361-3369.
[4] Volp K, Mathews S, Timms P, et al. Peptide immunization of guinea pigs against Chlamydia psittaci(GPIC agent)infection induces good vaginal secretion antibody response, in vitro neutralization and partial protection against live challenge. Immnnol Cell Biol, 2001, 79(3):245-250.
[5] Kawa DE, Stephens RS. Antigenic topology of chlamydial PorB protein and identification of targets for immune neutralization of infectivity. J Immunol, 2002, 168(10):5184-5191.
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[7] Su H, Messer R, Whitmire W, et al. Vaccination against chlamydial genital tract infection after immunization with dendritic cells pulsed ex vivo with nonviable Chlamydiae. J Exp Med, 1998, 188(5):809-818.
[8] Shaw J, Grund V, Durling L, et al. Dendritic cells pulsed with a recombinant chlamydial major outer membrane protein antigen elicit a CD4(+)type 2 rather than type 1 immune response that is not protective. Infect Immun, 2002, 70(3):1097-1105.
[9] Lu H, Xing Z, Brunham RC. GM-CSF transgene-based adjuvant allows the establishment of protective mucosal immunity following vaccination with inactivated Chlamydia trachomatis. J Immunol, 2002, 169(11):6324-6331.
[10] Pal S, Davis HL, Peterson EM, et al. Immunization with the Chlamydia trachomatis mouse pneumonitis major outer membrane protein by use of CpG oligodeoxynucleotides as an adjuvant induces a protective immune response against an intranasal chlamydial challenge.Infect Immun, 2002, 70(9):4812-4817.
[11] Zhang D, Yang X, Berry J, et al. DNA vaccination with the major outer-membrane protein gene induces acquired immunity to Chlamydia trachomatis(mouse pneumonitis)infection. J Infect Dis, 1997, 176(4):1035-1040.
[12] Zhang DJ, Yang X, Shen C, et al. Characterization of immune responses following intramuscular DNA immunization with the MOMP gene of Chlamydia trachomatis mouse pneumonitis strain. Immunology,1999, 96(2):314-321.
[13] Moore T, Ananaba GA, Bolier J, et al. Fc receptor regulation of protective immunity against Chlamydia trachomatis. Immunology, 2002,105(2):213-221.
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[15] Dong-Ji Z, Yang X, Shen C, et al. Priming with Chlamydia trachomatis major outer membrane protein(MOMP)DNA followed by MOMP ISCOM boosting enhances protection and is associated with increased immunoglobulin A and Thl cellular immune responses. Infect Immun.2000, 68(6):3074-3078.
[16] Vanrompay D, Cox E, Volckaert G, et al. Turkeys are protected from infection with Chlamydia psittaci by plasmid DNA vaccination against the major outer membrane protein. Clin Exp Immunol, 1999, 118(1):49-55.
[17] Pal S, Barnhart KM, Wei Q,et al. Vaccination of mice with DNA plasmids coding for the Chlamydia trachomatis major outer membrane protein elicits an immune response but fails to protect against a genital challenge. Vaccine, 1999, 7(5):459-465.
[18] Hechard C, Grepinet O, Rodolakis A. Evaluation of protection against Chlamydophila abortus challenge after DNA immunization with the major outer-membrane protein-encoding gene in pregnant and non-pregnant mice. J Med Microbiol, 2003, 52(Pt 1):35-40.