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����-18��һ���·��ֵ�ϸ������,���ж�������ѧ����.��ϵͳ�������Ⱦ�Ķ���ģ������ʾ�˽�ǿ�Ŀ��������.����-18��ϵͳ�������Ⱦ���ڷ�����������������Ӱ��,����Ҫ���û��ƿ�����ͨ���յ�Th1��ֳ������������-�ö�ʵ���䱣������.����,����-18�ڿ�ϵͳ�������Ⱦ�Ķ���ģ����Ҳ��ʾ�˽Ϻõ�Ӧ��ǰ��.
[2] Torigoe K,Ushio S,Okura T,et al.Purification and characterization of the human interleukin-18 receptor.J Biol Chem,1997,272(41):25737-25742.
[3] Kim SH,Reznikov LL,Stuyt RJ,et al.Functional reconstitution and regulation of IL-18 activity by the IL-18R beta chain.J Immunol,2001,166(1):148-154.
[4] Novick D,Kim SH,Fantuzzi G,et al.Interleukin-18 binding protein:a novel modulator of the Th1 cytokine response.Immunity,1999,10(1):127-136.
[5] Mencacci A,Bacci A,Cenci E,et al.Interleukin 18 restores defective Thl immunity to Candida albicans in caspase 1-deficient mice.Infect Immun,2000,68(9):5126-5131.
[6] Stuyt RJ,Netea MG,Verschueren I,et al.Role of interleukin-18 in host defense against disseminated Candida albicans infection.InfectImmun,2002,70(6):3284-3286.
[7] Okamura H,Tsutsi H,Komatsu T,et al.Cloning of a new cytokine that induces IFN-gamma production by T cells.Nature,1995,378(6552):88-91.
[8] Yoshimoto T,Takeda K,Tanaka T,et al.IL-12 up-regulates IL 18 receptor expression on T cells,Th1 cells,and B cells:synergism with IL-18 for IFN-gamma production.J Immunol,1998,161(7):3400-3407.
[9] Netea MG,Stuyt RJ,Kim SH,et al.The role of endogenous interleukin(IL)-18,IL-12,IL-1beta,and tumor necrosis factor-alpha in the production of interferon-gamma induced by Candida albicans in human whole-blood cultures.J Infect Dis,2002,185(7):963.
[10] Cenci E,Mencacci A,Del Sero G,et al.IFN-gamma is required for IL-12 responsiveness in mice with Candida albicans infection.J Immunol,1998,161(7):3543-3550.
[11] Vankayalapati R,Wizel B,Lakey DL,et al.T cells enhance production of IL-18 by monocytes in response to an intracellular pathogen.J Immunol,2001,166(11):6749-6753.
[12] Matsui K,Yoshimoto T,Tsutsui H,et al.Propionibacterium acnes treatment diminishes CD4 + NK1.1 + T cells but induces type I Tcells in the liver by induction of IL-12 and IL-18 production from Kupffer cells.J Immunol,1997,159(1):97-106.
[13] Takeda K,Tsutsui H,Yoshimoto T,et al.Defective NK cell activity and Thl response in IL-18-deficient mice.Immunity,1998,8(3):383-390.
[14] Micallef MJ,Ohtsuki T,Kohno K,et al.Interferon-gamma-inducing factor enhances T helper 1 cytokine production by stimulated human T cells:synergism with interleukin-12 for interferon-gamma produc tion.Eur J Immunol,1996,26(7):1647-1651.
[15] Spaccapelo R,Del Sero G,Mosci P,et al.Early T cell unresponsiveness in mice with candidiasis and reversal by IL-2:effect on T helper cell development.J Immunol,1997,158(5):2294-2302.
[16] Djeu JY,Liu JH,Wei S,et al.Function associated with IL-2 receptor-beta on human neutrophils.Mechanism of activation of antifungal activity against Candida albicans by IL-2.J Immunol,1993,150(3):960-970.
[17] Baltch AL,Smith RP,Franke MA,et al.Effects of cytokines and fluconazole on the activity of human monocytes against Candida albicans.Antimicrob Agents Chemother,2001,45(1):96-104.
[18] Kawakami K,Qureshi MH,Zhang T,et al.IL-18 protects mice against pulmonary and disseminated infection with Cryptococcus neoformans by inducing IFN-gamma production.J Immunol,1997,159(11):5528-5534.
[19] Qureshi MH,Zhang T,Koguchi Y,et al.Combined effects of IL-12 and IL-18 on the clinical course and local cytokine production in murine pulmonary infection with Cryptococcus neoformans.Eur J Im munol,1999,29(2):643-649.
[20] Nakamura S,Otani T,Ijiri Y,et al.IFN-gamma-dependent and-independent mechanisms in adverse effects caused by concomitant administration of IL-18 and IL-12.J Immunol,2000,164(6):3330.
[21] Kremer L,Dupre L,Wolowczuk I,et al.In vivo immunomodulation following intradermal injection with DNA encoding IL-18.J Immunol,1999,163(6):3226-3231.