|
��չ����
|
|
| ������Ϣ | |
 |
Supporting info |
|
PDFȫ�� |
|
[HTMLȫ��] |
|
����� |
| �����뷴�� | |
|
�������ù����� |
|
���� |
|
Email Alert |
|
���·��� |
|
���������Ϣ |
| ���Ĺؼ���������� | |
|
ӲƤ��,ϵͳ�� |
|
����άϸ�� |
|
��-ת���������� |
| ��������������� | |
|
���� |
|
���� |
|
������ |
| PubMed | |
|
Article by ���� |
|
Article by ���� |
|
Article by ������ |
��-ת���������Ӷ�ӲƤ������άϸ��Ӱ����о���չ
����1, ����2, ������1
1. ������ѧҽѧԺ������ɽҽԺƤ���� �Ϻ� 200040;
2. ������ѧҽѧԺ������ɽҽԺƤ����
ϵͳ��ӲƤ�����ߵij���άϸ����ԭ�ϳ����ࡢ�ֽ�����ǵ���Ƥ�����������֯��άӲ������Ҫ���̡��˹�����,��-ת�����������Ǵ̼�����άϸ���ϳɽ�ԭ����Ҫ����,��ͨ�������άϸ����Ĥ�ϵ���������,����Smad�����ź�ת��;��,����Ϣ������ϸ������,����ת¼�����ϵ����ͽ�ԭ�Ļ���ת¼�ͷ��롣ͬʱ,��-ת���������ӵ�����Ҳ�ܵ�����ϸ�����ӵ�Ӱ��,������������ӵ�ʧ��¼����ķ����ͷ�չ��
1. ������ѧҽѧԺ������ɽҽԺƤ���� �Ϻ� 200040;
2. ������ѧҽѧԺ������ɽҽԺƤ����
1. ������ѧҽѧԺ������ɽҽԺƤ���� �Ϻ� 200040;
2. ������ѧҽѧԺ������ɽҽԺƤ����
[2] Jimenez SA,Hitraya E,Varga J.Pathogenesis of scleroderma.Collagen.Rheum Dis Clin North Am,1996,22(4):647-674.
[3] McGaha T,Saito S,Phelps RG,et al.Lack of skin fibrosis in tight skin(TSK) mice with targeted mutation in the interleukin-4R alpha and transforming growth factor-beta genes.J Invest Dermatol,2001,116(1):136-143.
[4] Lee TY,Chin GS,Kim WJ,et al.Expression of transforming growth factor beta 1,2,and 3 proteins in keloids.Ann Plast Surg,1999,43(2):179-184.
[5] Zhou LJ,Ono I,Kaneko F.Role of transforming growth factor-beta 1 in fibroblasts derived from normal and hypertrophic scarred skin.Arch Dermatol Res,1997,289(11):646-652.
[6] Querfeld C,Eckes B,Huerkamp C,et al.Expression of TG F-beta 1,beta 2 and-beta 3 in localized and systemic scleroderma.J Dermatol Sci,1999,21(1):13-22.
[7] Schmid P,Itin P,Cherry G,et al.Enhanced expression of transforming growth factor-beta type �� and type �� receptors in wound granulation tissue and hypertrophic scar.Am J Pathol,1998,152(2):485-493.
[8] Ihn H,Yamane K,Kubo M,et al.Blockade of endogenous transforming growth factor beta signaling prevents up-regulated collagen synthesis in scleroderma fibroblasts:association with increased expression of transforming growth factor beta receptors.Arthritis Rheum,2001,44(2):474-480.
[9] Ihn H,Tamaki K.Increased phosphorylation of transcription factor Sp1 in scleroderma fibroblasts:association with increased expression of the type ��collagen gene.Aet hritis Rheum,2000,43(10):2240-2247.
[10] Jelaska A,Kom JH.Role of apoptosis and transforming grovth factor beta1 in fibroblast selection and activation in systemic sclerosis.Arthritis Rheum,2000,43(10),2230-2239.
[11] Zhou X,Tan FK,Stivers DN,et al.Microsatellites and intragenic polymorphisms of transforming growth factor beta and platelet-derived growth factor and their receptor genes in Native Americans with systemic sclerosis(scleroderma):a preliminary analysis showing no genetic association.Arthritis Rheum,2000,43(5):1068-1073.
[12] Reeves WB,Andreoli TE.Transforming growth factor beta contributes to progressive diabetic nephropathy.Proc Natl Acad Sci U S A,2000,97(14):7667-7669.
[13] Muldoon LL,Rodland KD,Magun BE.Transforming growth factor beta and epidermal growth factor alter calcium influx and phosphatidylinositol turnover in rat-1 fibroblasts.J Biol Chem,1988,263(35):18834-18841.
[14] Chen SJ,Artlett CM,Jimenez SA,et al.Modulation of human alphal(��)procollagen gene activity by interaction with Sp1 and Sp3 transcription factors in vitro.Gene,1998,215(1):101-1 10.
[15] Inagaki Y,Nemoto T,Nakao A,et al.Interaction between GC box binding factors and Smad proteins modulates cell lineage-specific alpha 2(I)collagen gene transcription.J Biol Chem,2001,276(19):16573-16579.
[16] Poncelet AC,Schnaper HW.Sp1 and Smad proteins cooperate to mediate transforming growth factor-beta 1 induced alpha 2(I) collagen expression in human glomerular mesangial cells.J Biol Chem,2001,276(10):6983-6992.
[17] Verrecchia F,Chu ML,Mauviel A.Identification of novel TGF-beta/Smad gene targets in dermal fibroblasts using a combined cDNA microarray/promoter transactivation approach.J Biol Chem,2001,276(20):17058-17062.
[18] Shi-wen X,Pennington D,Holmes A,et al.Autocrine overexpression of CTGF maintains fibrosis:RDA analysis of fibrosis genes in systemic sclerosis.Exp Cell Res,2000,259(1):213-224.
[19] Kikuchi K,Kadono T,Ihn H,et al.Growth regulation in scleroderma fibroblasts:increased response to transforming growth factor-beta 1.J Invest Dermatol,1995,105(1):128-132.
[20] Duncan MR,Frazier KS,Abramson S,et al.Connective tissue growth factor mediates transforming growth factor beta-induced collagen synthesis:down-regulation by cAMP.FASEB J,1999,13(13):1774-1786.
[21] Tredget EE,Wang R,Shen Q,et al.Transforming growth factor-beta mRNA and protein in hypertrophic scar tissues and fibroblasts:antagonism by IFN-alpha and IFN-gamma in vitro and in vivo.J Interferon Cytokine Res,2000,20(2):143-151.
[22] Yamamoto T,Eckes B,Krieg T.Effect of interleukin-10 on the gene expression of type �� collagen,fibronectin,and decorin in human skin fibroblasts:differential regulation by transforming growth factor-beta and monocyte chemoattractant protein-1.Biochem Biophys Res Commun,2001,281(1):200-205.