|
��չ����
|
|
| ������Ϣ | |
 |
Supporting info |
|
PDFȫ�� |
|
[HTMLȫ��] |
|
����� |
| �����뷴�� | |
|
�������ù����� |
|
���� |
|
Email Alert |
|
���·��� |
|
���������Ϣ |
| ���Ĺؼ���������� | |
|
����12 |
|
ϵͳ�������Ⱦ |
| ��������������� | |
|
���������� |
|
�������У |
| PubMed | |
|
Article by |
|
Article by |
����12�ڿ�ϵͳ�������Ⱦ�е�Ӧ��
����������, �������У
���пƼ���ѧͬ��ҽѧԺ����Э��ҽԺƤ����
����12�������嶼����������ͬ�Ķ��������ɵ����������ӡ������ж�ܡ�����12�ڶ������ģ���о���ʾ����ϵͳ�������Ⱦ������,�����ÿ�����ͨ�������ø�����,����Th1/Th2ƽ�⼰�յ��������������ӡ�O2-�IJ�����ʵ�ֵġ�
[2] Kobayashi M,Fitz L,Ryan M,et al.Identification and purification of natural killer cell stimulatory factor(NKSF),a cytokine with multiple biologic effects on human lymphocytes.J Exp Med,1989,170(3):827-844.
[3] Lieberman MD,Sigal RK,Williams NN,et al.Natural killer cell stimulatory factor(NKSF) augments natural killer cell and antibody-dependent tumoricidal response against colon carcinoma cell lines.J Surg Res,1991,50(4):410-415.
[4] Gately MK.Interleukin-12:potential clinical application in the treatment of chronic viral hepatitis.J Viral Hepatitis,1997,4(Suppl 1):33-39.
[5] Cassatella MA,Meda I,Gasperini S,et al.Interleukin-12 production by human polymorphonuclear leukocytes.Eur J Immunol,1995,25(1):1-5.
[6] Brunda MJ.Interleukin-12.J Leukoc Biol,1994,55(2):280-288.
[7] Hasko G,Szabo C.IL-12 as a therapeutic target for pharmacological modulation in immune-mediated and inflammatory diseases:regulation of Th1/Th2 response.Br J Pharm,1999,127(6):1295-1304.
[8] Zhou P,Sieve MC,Bennett J,et al.IL-12 prevents mortality in mice infected with histoplasma capsulatum through induction of IFN-gamma.J Immunol,1995,155(2):785-795.
[9] Kamijo R,Harada H,Matsuyama T,et al.Requirement for transcription factor IRF-1 in NO synthase induction in macrophages.Science,1994,263(5153):1612-1615.
[10] Cenci E,Romani L,Mencacci A,et al.IL-4 and IL-10 inhibit nitric oxide-dependent macrophage killing of Candida albicans.Eur J Immunol,1993,23(5):1034-1038.
[11] Kawakami K,Qureshi MH,Zhang T,et al.Interferon-garmma(IFN-��)-dependent protection and synthesis of chemoattractants for mononuclear leucocytes caused by IL-12 in the lungs of mice infected with Cryptococcus neoformans.Clin Exp Immunol,1999,117(1):113-122.
[12] Kawakami K,Tohyama M,Qifeng X,et al.Expression of cytokines and inducible nitric oxide synthase mRNA in the lungs of mice infected with Cryptococcus neoformans:effects of interleukin-12.Infect Immun,1997,65(4):1307-1312.
[13] Zhou P,Sieve MC,Tewari RP,et al.Interleukin-12 modulates the protective immune response in SCID mice infected with Histoplasma capsulatum.Infect Immun,1997,65(3):936-942.
[14] Roilides E,Tsaporidon S,Kadiltsoglou I,et al.IL-12 enhances antifungal activity of human mononuclear phagocytes against aspergillus fumigatus:implications for a gamma-interferon-independent pathway.Infect Immun,1999,67(6):3047-3050.
[15] Kawakami K,Qifeng X,Tohyama M,et al.Contribution of tumour necrosis factor-alpha(TNF-alpha) in host defence mechanism against Cryptococcus neoformans.Clin Exp Immunol,1996,106(3):468-474.
[16] Kawakami K,Tohyama M,Xie Q,et al.IL-12 protects mice against pulmonary and disseminated infection caused by Cryptococcus neoformans.Clin Exp Immunol,1996,104(2):208-214.
[17] Romani L,Mencacci A,Cenci E,et al.Neutrophil production of IL- 12 and IL- 10 in candidiasis and efficancy of IL- 12 therapy in neutropenic mice.J Immunol,1997,158(11):5349-5356.
[18] Clemons KV,Brummer E,Stevens DA,et al.Cytokine treatment of central nervous system infection:efficacy of interleukin12 alone and synergy with conventional antifungal therapy in experimental cryptococcosis.Antimicrob Agents Chemother,1994,38(3):460-464.
[19] Zhang T,Kawakami K,Qureshi MH,et al.Interleukin-12(IL12) and IL-18 synergistically induce the fungicidal activity of murine peritoneal exudate cells against Cryptococcus neoformans through production of gamma,interferon by natural killer cells.Infect Immunol,1997,65(9):3594-3599.
[20] Qureshi MH,Zhang T,Koguchi Y,et al.Combined effects of IL-12 and IL-18 on the clinical course and local cytokine production in murine pulmonary infection with Cryptococcus neoformans.Eur J Immunol,1999,29(2):643-649.
[21] Ahuja SS,Mummidi S,Malech HL,et al.Human dendritic cell(DC)-based anti-infective therapy:engineering DCs to secrete fumctional IFN-��and IL- 12.J Immunol,1998,161(2):868-876.
[22] Jiang CY,Magee DM,Cox RA,et al.Construction of a singlechain IL-12-expressing retroviral vector and its application in cytokine gene therapy against experimental coccidioidomycosis.Infect Immun,1999,67(6):2996-3001.