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Psoriasis is a chronic inflammatory disease of unknown pathogenesis. Previous studies revealed that the genome of patients with psoriasis is instable. Damage in bone marrow hematopoietic stem cells has been reported to occur during the occurrence and development of psoriasis, which is manifested as the mutation of somatic cell chromosome followed by the development of leukemia, especially acute promyelocytic leukemia. Promyelocytic leukemia genes are primarily responsible for the development of promyelocytic leukemia, and also play an important role in maintaining genomic stability in patients with psoriasis. Further research is required to define the roles of promyelocytic leukemia genes.