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Trichomoniasis is a highly prevalent sexually transmitted disease worldwide, which is often asymptomatic and has been associated with potentially serious sequelae. Recent genomic and proteomic studies have identified several protein families and novel surface proteins involved in host-pathogen interactions and trichomoniasis pathogenesis. Advances in molecular techniques for trichomoniasis diagnosis have led to a better understanding of the epidemiology of Trichomonas vaginalis infection, as well as of the interactions between T.vaginalis and other sexually transmitted disease pathogens. Trichomoniasis is poorly controlled at present and there has been increasing levels of drug resistance in T.vaginalis recently. Screening is strongly recommended for populations at high risk.