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Systemic lupus erythematosus ��SLE�� is a complex, chronic and autoimmune disease with unclear pathogenesis. Recent studies have shown that abnormality in epigenetic modifications, including microRNAs and DNA methylation, may play an important role in the occurrence and development of SLE. It has been demonstrated that microRNAs, as a group of small non-coding single-stranded RNAs, take part in the occurrence and development of SLE, and their interaction with DNA methylation may affect the occurrence and development of SLE via regulating intracellular gene expression. The authors summarize the roles of abnormal expression of microRNAs as well as their interaction with DNA methylation in the pathogenesis of SLE, aiming to offer a new clue into the research in SLE.

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