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Postherpetic neuralgia ��PHN�� refers to a painful condition that persists for 4 weeks after the rash of shingles has gone away. The incidence of PHN is age-related. PHN may feel like a burning pain, electric shock, knifelike pain, paresthesia, etc. It often affects the quality of life of patients from the aspects of sleep, emotion, and so on. Pregabalin, a new type of gamma-aminobutyric acid receptor agonist, can control PHN via binding to the calcium channel alpha 2-delta type 1 subunit in the central nervous system, altering the conformation of alpha 2-delta subunit, and thereby restoring the calcium channel to nearly normal level. Both flexible- and fixed-dose of pregabalin for 4 to 12 weeks have been reported to be markedly effective for the control of PHN and improvement of patients' quality of life. Long-term pregabalin exhibits good tolerability and few drug interactions.