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Regulatory T cells are a kind of T cell subset with immunosuppressive properties. The clarification of Foxp3 gene function and progress in molecular biological studies have brought new insights into regulatory T cells. It has been elucidated that regulatory T cells have negative immunoregulatory effect, and can inhibit the activation and proliferation of, as well as the secretion of cytokines by, CD4+ and CD8+ T cells. Studies have shown that regulatory T cells play a crucial role in the pathogenesis, treatment and prognosis of dermatoses. The authors make a summary on the roles of regulatory T cells in inflammatory, autoimmune dermatoses and skin tumors.