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Colchicine, a toxic natural product and the active principle of Colchicum autumnale, has been known since antiquity for its medicinal uses. It possesses anti-mitotic, anti-inflammatory and immunosuppressive activities. There are two non-dermatologic absolute indications of colchicine: acute gout crisis and familial Mediterranean fever. Several uncontrolled clinical studies have shown exciting outcomes in the treatment of some dermatologic diseases with colchicines, such as neutrophilic dermatoses, psoriasis, bullous dermatoses, and so on. Low dose of colchicine is well tolerable with less adverse reactions, while large dose of colchicine is associated with considerable toxic and side effects. Hence, attention should be paid to adverse reactions and drug interactions as well as relevant parameters during the clinical application of colchicines.

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