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Acne is a most common chronic inflammation disease of the pilosebaceous gland with a variety of clinical presentations�� Excessive androgen and inflammation play an important role in the pathogenesis of acne�� The etiology of acne remains unanswered, and multiple studies have indicated that hereditary factors contribute to the susceptibility to acne�� It has been revealed that androgen receptor gene��CYP11α gene�� CYP17A1 gene and TNFα gene are related with the development of acne�� This paper presents advances in the relationship between acne and polymorphisms in both androgen related genes and inflammation-mediating genes.