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To report a case of bullous pemphigoid whose severity is parallel with peripheral blood eosinophil count. A 65-year-old man presented with generalized erythema and blisters for 1 month, which had been aggravated for 15 days. Skin examination revealed irregularly sized blisters with grass-yellow fluid developing on normal skin or erythematous patches in the head, neck, face, trunk, limbs and perineum. Nikolsky′s sign was negative. Erythematous erosions were observed and some lesions were covered with grey-brown crusts. The chest, back and limbs were predominantly affected by these lesions. Histopathological, direct immunofluorescence ��DIF�� and indirect immunofluorescence ��IIF�� examination as well as DIF examination of salt-split skin revealed characteristic changes suggestive of bullous pemphigoid. After admission, he was sequentially given 3 sessions of pulse treatment with high dose glucocorticoids. Routine blood test was performed with regular interval during the treatment, and the results of these tests implied that peripheral blood eosinophil count is parallel to the severity of bullous pemphigoid.