[an error occurred while processing this directive] ����Ƥ���Բ�ѧ��־ 2011, 37(6) 335-336 DOI:     ISSN: 2096-5540 CN: 32-1880/R

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PubMed
Article by Kong,Q.S
Article by Sang,h
Article by Zhang,m
Article by Hu,W.X
Article by Nie,t
Article by Yu,X.L
Article by Liu,f
Article by Yu,G.F

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A case of drug hypersensitivity syndrome accompanied by rhabdomyolysis

Abstract:

A 20-year-old female presented with generalized skin eruptions, fever and hepatic damage for more than 20 days. Skin examination demonstrated nonpitting edema and flushing of the face and extremities as well as mild erythema of both lower eyelids with furfur-like fine scales all over the body surface. Laboratory examination showed that eosinophil count was 1.67 × 109/L, serum alanine transarninase ��ALT�� level 214 U/L, serum aspartate aminotransferase ��AST�� level 105 U/L, serum creatine kinase ��CK�� level 962 U/L, serum lactate dehydrogenase ��LD�� level 519 U/L, serum myoglobin level 608 ng/ml. Electromyogram ��EMG�� revealed myogenic lesions. The diagnosis of drug hypersensitivity syndrome accompanied by rhabdomyolysis was made. The patient was treated with intravenous methylprednisolone 40 mg once daily after hospitalization. One week after the initiation of treatment, clinical symptom improved with the normalization of liver and renal function and she was discharged from the hospital. No recurrence was noted during the follow up.

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