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Childhood generalized pustular psoriasis is rare, and accounts for about 0.6% of all the cases of psoriasis in children. Up to date, there has been no specific treatment for this disease in the world. Childhood generalized pustular psoriasis has its characteristics, and therapeutic effect and safety of drugs in children differ from those in adults, hence, the use of drugs in pediatric patients is limited and should be given more cautions, and the benefit and risk should be weighed sufficiently before the selection of drugs in clinical practice. It is generally believed that the course of systemic treatment in children should be no longer than half a year to avoid or reduce the long-term side effects of drugs. The authors review the advances in the treatment of childhood generalized pustular psoriasis with tretinoin, glucocorticoids, immunosuppressants, antibiotics, phototherapy and biological agents.