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Invading pathogens induce the organism into a state of oxidative stress followed by the release of massive reactive oxygen species by phagocytes. Once the balance between the generation and removal of reactive oxygen species is disturbed, oxidative damage to cells occurs. When confronting oxidative stress, pathogens express some antioxidants to trigger the anti-oxidative mechanisms and counteract the killing and damage mediated by oxidative stress. This review expounds the mechanisms underlying the oxidative damage to pathogenic fungi by reactive oxygen species released from hosts, such as hydrogen peroxide, superoxide anion, hydroxyl radical, etc, and anti-oxidative stress response by antioxidants such as catalase and superoxide dismutase expressed by pathogenic fungi.

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