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A case of bezoar antidotal tablet-induced Stevens-Johnson syndrome complicated by acute pancreatitis and secondary cytomegalovirus infection is reported. A 20-year-old female presented with a 4-day history of painful oral, corneal and vulval erosions and ulcer with fever. Cutaneous examination revealed soybean-sized, edematous erythematous patches scattered over the body, some of these lesions were target-shaped with or without central vesicles and purpura. There were generalized hyperemia and erosions covered by white membranous material and yellow purulent secretions. After hospitalized with a diagnosis of Stevens-Johnson syndrome, she developed acute pancreatitis and upper gastrointestinal tract bleeding. Her condition improved markedly after timely management, but fever appeared subsequently. The results of blood routine test and serological tests for cytomegalovirus were suggestive of cytomegalovirus infection. The patient completely recovered after 2-week treatment with ganciclovir.