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Vitiligo is an acquired hypopigmented disease characterized by the destruction of melanocytes. Many scholars consider that the pathogenesis of vitiligo is mainly associated with immune abnormalities. Topical calcineurin inhibitors have favorable efficacy in the treatment of vitiligo, and the efficacy is associated with the treatment regimen, course, application sites, duration and stage of vitiligo, etc. The combination with narrow-band ultraviolet B, 308-nm excimer laser or other therapies may have synergistic effect on the efficiency of calcineurin inhibitors. Although calcineurin inhibitors are safe and effective in the treatment of vitiligo, further studies are needed to evaluate their long-term safety and stability.