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��Ƥ��Բ�ѧ��־ 2011, 37(2) 61-63 DOI: ISSN: 2096-5540 CN: 32-1880/R

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	PubMed
	Article by Jiang,Y.Q
	Article by Zeng,H.S
	Article by Chen,Q.L
	Article by Feng,S.Y
	Article by Chen,g

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A case of epidermolysis bullosa acquisita in childhood

Abstract:

A case of epidermolysis bullosa acquisita ��EBA�� in childhood is reported. A 12-year-old girl was hospitalized for a 3-month history of recurrent blisters, bullae and erosions on the trunk and limbs. The girl had mental retardation but no family history of similar disorders. The marriage between her parents was not consanguineous. Physical examination on admission revealed large erosions with moderate oozing on the hands and feet, around the knees and on the buttock and thighs. There were scattered tense blisters and bullae arising in normal skin or edematous erythema on the trunk and limbs. During the treatment course the patient suddenly developed a number of tense blisters over the whole integument on the trunk and limbs. Skin biopsy showed subepidermal bullae with moderate perivascular infiltration of neutrophils and eosinophils. Direct immunofluorescence ��DIF�� revealed linear IgG and C3 deposition along the basal membrane zone, which was on the dermal side of salt-split skin on indirect immunofluorescence ��IIF��. ELISA detected no serum anti-BP180 or -BP230 antibodies in the patient. A diagnosis of EBA was made. The patient was successfully controlled by intravenous steroids combined with oral tetracycline.

Keywords: Therapy

�ո�� 2010-09-15 �޻�� 2010-11-12 ��淢�� 2011-03-10

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[1] ��ｨ��. ��Դ��Ա�Ƥ�ɽ�֢��о��չ. ��Ƥ��Բ�ѧ��־��2006��32��1��41-44. [2] Woodley DT, Remington J, Chen M. Autoimmunity to type VII collagen: epidermolysis bullosa acquisita. Clin Rev Allergy Immunol, 2007, 33(10): 78-84. [3] Liu A, Yang DJ, Hsu S. A quick and simple serum test to differentiate bullous pemphigoid, epidermolysis bullosa acquisita, and anti-epiligrin cicatricial pemphigoid. Dermatol Online J, 2008, 14(7):3. [4] Ishii N, Hamada T, Dainichi T, et al. Epidermolysis bullosa acquisita: What’s new? J dermatol, 2010, 37(3): 220–230. [5]Powell J, Kirtschig G, Allen J, et al. Mixed imunobullous disease of childhood: a good response to antimicrobials. Br J Dermtol, 2001, 144: 769-774. [6]��Ԫ��. �Ļ��ҩ��ƴ��崯. ��ҽѧ��Ƥ��Բ�ѧ�ֲᣬ1998��24��3��129-131. [7] ��ϲѩ��淣��. ��ŵ��25��崯. �й��Ƥ��־��2006��22��11��