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Herpes simplex virus type 2 ��HSV-2�� and human immunodeficiency virus type 1 ��HIV-1��are synergistic copathogens. Biological and epidemiological evidence suggests that HSV-2 infection increases the risk of HIV-1 acquisition and may facilitate the transmission of HIV-1. This review focuses on the epidemiological relationship and biological interaction between HSV-2 and HIV-1. Based on these data, HSV-2 infection should be targeted as a risk factor for HIV-1 acquisition, and more prevention through behavioural interventions and antiviral suppression should be incorporated into the strategy for HIV-1 prevention.

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