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Th22 cells are a new subset of CD4+ T cells identified in recent years. They mainly secrete interleukin ��IL-22, IL-13 and IL-26, but not interferon-γ ��IFN-γ�� or IL-4, and exert their function mainly via IL-22. They can mediate inflammatory reactions, autoimmune diseases, tumors, etc, and play an important role in immune regulation, host defense and tissue repair. Most importantly, Th22 cells can modulate cell proliferation, differentiation and apoptosis. Studies have shown an abnormal expression of IL-22 in a variety of autoimmune diseases, hinting that Th22 cells are involved in T cell-mediated autoimmune diseases.

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