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Infantile hemangiomas are common benign tumor of infancy. Their etiology remains unknown. The initiation of infantile hemangiomas is reported to be a complex pathophysiological process with the involvement of several mechanisms. The authors review recent studies and new hypotheses on the cell origin of infantile hemangiomas, including placental origin theory, endothelial progenitor cell theory and metastatic niche theory, in hope to enhance clinician recognition of infantile hemangiomas. At present, there are numerous problems remaining unanswered. To clarify the cell origin of infantile hemangiomas will help to develop more effective treatment strategies for this entity.

[1] Bischoff J.Progenitor cells in infantile hemangioma. J Craniofac Surg,2009, 20 Suppl 1:695-697. [2] Constantijn G, Maurice VS, Peter S, et al. The Pathogenesis of Hemangiomas: A Review. Plast Reconstr Surg,.2006,117(2):29-35. [3] Burton BK, Schulz CJ, Angle B,et al. An increased incidence of haemangiomas in infants born following chorionic villous sampling. Prenat Diagnm, 1995, 15(3): 209-214. [4] Holmes LB.Chorionic villus sampling and hemangiomas. J Craniofac Surg, 2009 ,20 Suppl 1:675-677. [5] North PE, Waner M, Mizeracki A,et al.A Unique Microvascular Phenotype Shared by Juvenile Hemangiomas and Human Placenta. Arch Dermatol. 2001,137(5): 559-570. [6] North PE, Waner M, Mizeracki A, et al. A unique microvascular phenotype shared by juvenile hemangiomas and human placenta. Arch Dermatol, 2001,137:559–570. [7] Bree AF, Siegfried E, Sotelo-Avila C, Nahass G.Infantile hemangiomas: speculation on placental trophoblastic origin. Arch Dermatol, 2001,137(5):573-577. [8] Sun ZY, Yi CG, Zhao H et al.Infantile hemangioma is originated from placental trophoblast, fact or fiction? Med Hypotheses, 2008 ,71(3):444-448. [9] Barnés CM, Huang S, Kaipainen A,et al. Evidence by molecular profiling for a placental origin of infantile hemangioma.Proc Natl Acad Sci U S A,2005,102(52): 19097–19102. [10] Chang EI, Chang EI, Thangarajah H, et al.Hypoxia, hormones, and endothelial progenitor cells in hemangioma. Lymphat Res Biol,2007,5(4):237-243. [11] Boye E, Yu Y, Paranya G,et al.Clonality and altered behavior of endothelial cells from hemangiomas. J Clin Invest, 2001,107(6):745-752. [12] Khan ZA,Boscolo E,Picard A,et al. Multipotential stem cells recapitulate human infantile hemangioma in immunodeficient mice.J Clin Invest, 2008,118(7): 2592–2599. [13] Khan ZA, Melero-Martin JM, Wu X et al. Endothelial progenitor cells from infantile hemangioma and umbilical cord blood display unique cellular responses to endostatin. Blood. 2006, 108(3) : 915-921. [14] Kleinman ME, Tepper OM, Capla JM, et al. Increased circulating AC133+ CD34+ endothelial progenitor cells in children with hemangioma. Lymphat Res Biol, 2003,1:301–307. [15] North PE, Waner M, Mizeracki A, Mrak RE, Nicholas R, Kincannon J,Suen JY & Mihm MC, Jr. (2001) Arch. Dermatol. 137: 559–570. [16] Paget S. The distribution of secondary growths in cancer of the breast. Cancer Metastasis Rev,1989, 8(2):98-101. [17] Kaplan RN, Rafii S, Lyden D. Preparing the ‘‘Soil’’: the premetastatic niche. Cancer Res,2006, 66(23): 11089-11093. [18] Mihm MC Jr, Nelson JS.Hypothesis: the metastatic niche theory can elucidate infantile hemangioma development. J Cutan Pathol, 2010,37 Suppl 1:83-87. [19] Waner M, North PE, Scherer KA,et al. The nonrandom distribution of facial hemangiomas. Arch Dermatol,2003,139(7): 869-875.