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��Դ�ڳ�ʼTϸ����Th17ϸ�����·��ֵ�һ�಻ͬ��Th1��Th2��CD4+ Tϸ���������IL-17�� IL-6��IL-22�������������ӵ�ϸ�����ӣ��ڽ鵼������֢��Ӧ�����������Լ����ȷ��淢������Ҫ���á��о�������IL-17��HIV��Ⱦ�з����ſ���Ⱦ���ã�ͬʱ�ڿ�HIVϸ�����ӵ��������У�IL-17Ҳ������Ҫ���á���HIV��Ⱦ���ڣ�Th17ϸ��������ѪҺ��θ�����д�����������˥�ߣ�����Th17�ܷ񷢻ӿ��������ܻ���Ҫ������̽�����о���֤�����������ȹ����İе�ϸ����CCR5+ CCR6+ Th17��Th17��ΪHIV�µİ���ϸ��������Ϊ���̲��ṩ�µ����Ʋ��ԡ�

Abstract: Newly discovered Th17 cells which is from the initial T cells are a class different from the Th1, Th2 in CD4 + T cells. Its unique secretion of IL-17, IL-6, IL-22 and tumor necrosis factor (TNF-α ) and other cytokines has played an important role in mediating chronic inflammation, autoimmune diseases. Recent studies have shown that, IL-17 gets involved against HIV Th17 cells that derive from initial T cells are a newly discovered class of CD4+ T cells different from Th1 and Th2 cells. They secrete interleukin ��IL-17, IL-6, IL-22, tumor necrosis factor and other cytokines, and play an important role in mediating chronic inflammation, autoimmune diseases, etc. Recent studies have evidenced that IL-17 posseses a potent anti-HIV activity and exerts a crucial role in anti-HIV cytokine regulatory networks. In early HIV infection, there is a significant reduction or depletion of Th17 cells in peripheral blood and gastrointestinal tract. Nevertheless, further exploration is required to clarify the anti-viral function of Th17 cells. Studies have evidenced that the first target of HIV virus attacks is CCR5+CCR6+ Th17 cells. As a new target of HIV, Th17 cells are expected to provide new therapeutic strategy for AIDS treatment.