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Mycosis fungoides is the most common cutaneous T cell lymphoma. Epidermotropism, manifested as the infiltration of epidermis with atypical CD4+ T lymphocytes, may be observed at the early stage of mycosis fungoides, and disappear at the tumor stage. Current studies concerning epidermotropism in mycosis fungoides are mainly focused on the following two aspects, i.e., the interaction of chemokines expressed by keratinocytes with their receptors on the surface of lymphocytes, such as IP-10/CXCR3, SDF-1/CXCR4, TARC/CCR4, as well as the interaction between intraepithelial Langerhans cells and regulatory T cells.

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