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Deregulation of signaling pathways is commonly accompanied with the initiation, development, infiltration and metastasis of many kinds of tumors. Basal cell carcinoma ��BCC�� is a most common form of skin malignancy. Numerous studies have shown that many signaling pathways including Wnt, epidermal growth factor receptor ��EGFR��, Notch, transforming growth factor ��TGF�� β/bone morphogenetic protein ��BMP��, FasL-Fas, PI3K-AKT, mitogen-activated protein kinase ��MAPK��, nuclear factor kappa B, etc, play an essential role in the biological behaviors of BCC. Of these signaling pathways, Hedgehog is the core pathway. Most importantly, there are some cross-talks between Hedgehog pathway and Wnt, EGFR, TGFβ/BMP, Notch pathway in the signal transduction in BCC. Researches on these signaling pathways in BCC may contribute to the illumination of pathogenesis of BCC and searches for accurate therapeutic targets.

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