1. ���ҽ�ƴ�ѧ��ҽԺ
2. ���ҽ�ƴ�ѧ��ҽԺƤ���Բ���/����Դ��������о���

Ƥ�����ϻ�����Ӱ��Ƥ�����ݣ������Բ�������Ƥ��������Ƥ�������������������Ե��ٴ������Լ���Ӧ����֯ѧ����������ѧˮƽ�ĸı䡣�����о���������Ȼ���еĶ���ֲ�����˲Ρ��̲衢ʯ��Ⱦ���һ���Ŀ������߷��䡢����������������������ɻ��������������ã�������Ч����Ƥ�����ϻ�����������Դ�㷺��������Ӧ�٣����й�����Ӧ��ǰ�����������������ֲ�ֲͬ����Ƥ�����ϻ���Ԥ���������е����û��ơ���Ч�ȷ�����о���

Skin photoaging can not only affect individual appearance, but also cause various skin diseases and tumors. It is characterized by clinical, histological and molecular biological changes. Numerous studies have shown that botanicals such as ginseng, green tea and pomegranate have free radical scavenging activity as well as some protective effects against ultraviolet radiation, allergy, oxidation stress and tumors. A promising prospect of botanicals is expected in the prevention and treatment of skin photoaging for their various biological activity, ready acquisition and slight side effects. The authors review recent advances in action mechanisms and therapeutic effects of different botanicals in the prevention and treatment of skin photoaging.

�ο����� [1] Afaq F,Mukhtar H.Botanical antioxidants in the prevention of photocarcinogenesis and photoaging.Experimental Dermatology,2006,15(9):678–684. [2] Lee YJ,Kim HY,Kang KS,et al.The chemical and hydroxyl radical scavenging activity changes of ginsenoside-Rb1 by heat processing.Bioorg Med Chem Lett,2008,18(16):4515-4520. [3] Park BJ,Lim YS,Lee HJ,et al. Anti-oxidative effects of Phellinus linteus and red ginseng extracts on oxidative stress-induced DNA damage.BMB Rep,2009,42(8):500-505. [4] Kim YG,Sumiyoshi M, Sakanaka M,et al.Effects of ginseng saponins isolated from red ginseng on ultraviolet B-induced skin aging in hairless mice.Eur J Pharmacol, 2009,602(1):148-156. [5] Kang TH,Park HM,Kim YB,et al.Effects of red ginseng extract on UVB irradiation-induced skin aging in hairless mice.Journal of Ethnopharmacology,2009,123(3):446–451. [6] Cho S,Won CH,Lee DH,et al.Red ginseng root extract mixed with Torilus fructus and Corni fructus improves facial wrinkles and increases type I procollagen synthesis in human skin: a randomized,double-blind,placebo-controlled study.J Med Food,2009,12(6):1252-1259. [7] Katiyar SK,Ahmad N,Mukhtar H.Green tea and skin. Arch Dermatol,2000,136(8):989-994. [8] Vayalil PK,Mittal A,Hara Y, et al. Green tea polyphenols prevent ultraviolet lightinduced oxidative damage and matrix metalloproteinases expression in mouse skin. J Invest Dermatol,2004,122(6):1480-1487. [9] Kim J,Hwang JS,Cho YK,et al.Protective effects of (-)-epigallocatechin-3-gallate on UVA- and UVB-induced skin damage.Skin Pharmacol Appl Skin Physiol,2001,14(1):11-19. [10]Li YH,Wu Y,Wei HC,et al.Protective effects of green tea extracts on photoaging and Photommunosuppression.Skin Research and Technology,2009,15(3):338-345. [11]Brisdelli F,D’Andrea G,Bozzi A.Resveratrol: a natural polyphenol with multiple chemopreventive properties.Curr Drug Metab,2009,10(6):530-546. [12]Valenzano DR,Terzibasi E,Genade T,et a1.Resveratrol prolongs lifespan and retards the onset of age-related marker in a short-lived vertebrate.Curr Biol,2006,16(3):296-300. [13]Adhami VM,Afaq F,Ahamd N.Suppression of ultraviolet B exposure-mediated activation of NF-kappaB in normal human keratinocytes by resveratrol.Neoplasia,2003,5(1):74-82. [14]Moammir Hasan Aziz,Farrukh Afaq,Nihal Ahrnad.Prevention of Ultraviolet-B Radiation Damage by Resveratrol in Mouse Skin Is Mediated via Modulation in Survivin.Photochemistry and Photobiology,2005,81:25-31. [15]Jurenka JS,Therapeutic applications of pomegranate (Punica granatum L.): a review.Altern Med Rev,2008,13(2):128-144. [16]Zaid MA,Afaq F,Syed DN,et al.Inhibition of UVB-mediated oxidative stress and markers of photoaging in immortalized HaCaT keratinocytes by pomegranate polyphenol extract POMx. Photochem Photobiol,2007,83(4):882-888. [17]Afaq F,Zaid MA,Khan N.et al.Protective effect of pomegranate-derived products on UVB-mediated damage in human reconstituted skin.Exp Dermatol,2009,18(6):553-561. [18]Lee YR,Noh EM,Jeong EY,et al.Cordycepin inhibits UVB-induced matrix metalloproteinase expression by suppressing the NF-κB pathway in human dermal fibroblasts.Exp Mol Med, 2009,41(8):548-554. [19]�,Ҷ�߽�,��ڵ�.��ݶ��Ƕ�8-MOP��UVA�յ�Ƥ������άϸ�����ϻ����׿�����.ʱ���ҽ��ҩ,2009,20(5):1074-1076. [20] Lei H, Wang B, Li WP,et al.Anti-aging effect of astragalosides and its mechanism of action. Acta Pharmacol Sin,2003,24(3):230-234. [21]����,������,�����.«�����Ƕ��в��������յ��˽����γ�ϸ�������׽���-8��Ӱ���о�.�й�ҩ��,2008,19(15):1131-1133. [22]Jae-We Cho,Kun Park,Gi Ryang Kweon,et al.Curcumin inhibits the expression of COX-2 in UVB-irradiated human keratinocytes (HaCaT) by inhibiting activation of AP-1:p38 MAP kinase and JNK as potential upstream targets. EXPERIMENTAL and MOLECULAR MEDICINE, 2005,3(37)186-192. [23]Zhu M,Zhang Y,Cooper S,et al.PhaseII EnzymeInducer,Sulforaphane,Inhibits UVB-Induced AP-1 Activation in Human Keratinocytes by a Novel Mechanism.Mol Carcinog,2004,41(3):179-186. [24]Ho JN,Lee YH,Lee YD,et al.Inhibitory effect of Aucubin isolated from Eucommia ulmoides against UVB-induced matrix metalloproteinase-1 production in human skin fibroblasts[J]. Biosci Biotechnol Biochem,2005,69(11):2227-2231. [25]Hwang IK,Yoo KY,Kim DW,et al.An extract of Polygonum multiflorum protects against free radical damage induced by ultraviolet B irradiation of the skin. Braz J Med Biol Res,2006,39(9):1181-1188. [26]Moore JO,Wang Y,Stebbins WG,et al.Photoprotective effect of isoflavone genistein on ultraviolet B induced pyrimidine dimer formation and PCNA expression in human reconstituted skin and its implications in dermatology and prevention of cutaneous carcinogenesis.Carcinogenesis,2006,27(8):1627-1635. [27]Svobodová A,Zdarilová A,Malisková J,et al.Attenuation of UVA-induced damage to human keratinocytes by silymarin.J Dermatol Sci,2007,46(1):21-30. [28]Turkoglu M,Cigirgil N.Evaluation of black tea gel and its protection potential against UV [J].Int J Cosmet Sci,2007,29(6):437-442.