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| PubMed | |
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Article by Yu,l |
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Article by Zhou,X.H |
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Hereditary susceptibility in leprosy
Most leprosy?۲related epidemiological studies are based on the comparison of frequencies of genetic markers in case?۲control designs using candidate genes. Many susceptibility and resistance genes, such as interleukin ��IL��?۲10 gene, vitamin D receptor ��VDR�� gene, and NRAMP1 gene, have been newly identified. Genomic scans using family?۲based designs also have determined some chromosome regions which may be asso ciated with leprosy. With the progress in human genome research, more susceptibility and resistance genes will be found, and these genetic markers will be applied to gene diagnosis and prognosis prediction so as to screen high?۲risk populations and break the chain of transmission of leprosy.