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Regulatory B cells ��Bregs�� belong to a B?۲cell subset with immunoregulatory activity, which has been evidenced in mice. The origin and phenotype of the cell subset are controversial. Bregs suppress immune responses mainly by direct cell-cell interactions, secretion of cytokines such as interleukin ��IL)-10, transforming growth factor ��TGF)-β, etc. It has been demonstrated that Bregs are associated with systemic lupus erythematosus as well as contact hypersensitivity ��CHS��, and involved in many diseases and biological processes. This review focuses on the identification, origin, function, action mechanism, relationship with diseases, prospect and challenges in researches of Bregs.

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