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The pathogenesis of psoriasis is closely associated with immune system. Most of recent studies have suggested that psoriasis is a mixed Th1/Th17 immunological disease. Besides dendritic cells, T cells, keratinocytes and Th1 type cytokines such as interleukin ��IL-12 and IL-18, Th17 type cytokines such as IL-23 and IL-22 also participate in the development of psoriasis. Th17 type immune response may play an essential role in the pathogenesis of psoriasis.

�ο����ף� 1. Christophers E. Psoriasis — epidemiology and clinical spectrum.Clin Exp Dermatol, 2001(4),26:314-320. 2. Brian J. Nickoloff. Skin innate immune system in psoriasis: friend or foe? J Clin Invest,1999,104(9):1 161-1 164. 3. Amy S. Paller, Elaine C. Siegfried, Richard G. Langley,et al. Etanercept Treatment for Children and Adolescents with Plaque Psoriasis. N Engl J Med 2008,358:241-251. 4. Andrew Blauvelt. T-Helper 17 Cells in Psoriatic Plaques and Additional Genetic Links between IL-23 and Psoriasis.J Invest Dermatol, 2008,128(5), 1 064–1 067. 5. Frank O. Nestle,Curdin Conrad,Adrian Tun-Kyi,et al. Plasmacytoid predendritic cells initiate psoriasis through interferon - production.JEM, 2005,202: 135–143. 6. Yihong Yao, Laura Richman, Chris Morehouse,et al. Type I Interferon: Potential Therapeutic Target for Psoriasis? PLoS One 2008, 3(7): e2737 7. Lisa C. Zaba, Judilyn Fuentes-Duculan, Narat John Eungdamrong,et al. Psoriasis is characterized by accumulation of immunostimulatory and Th1/Th17 cell polarizing myeloid dendritic cells. J Invest Dermatol. 2009,129(1): 79–88. 8. Michelle A. Lowes, Francesca Chamian, Maria Veronica Abello, et al. Increase in TNF-α and inducible nitric oxide synthase-expressing dendritic cells in psoriasis and reduction with efalizumab (anti-CD11a). PNAS, 2005,102(52):19 057–19 062. 9. Charles N. Ellis, Gerald G. Krueger.Treatment of Chronic Plaque Psoriasis by Selective Targenting of Menory Effector T Lymphocytes. N Engl J Med, 2001, 345:248-255 10. Conrad C, Boyman O, Tonel G, et al. Alpha1beta1 integrin is crucial for accumulation of epidermal T cells and the development of psoriasis. Nat Med 2007, 13:836-842. 11. Michael N. Hedrick, Anke S. Lonsdorf, Aiko-Konno Shirakawa,et al. CCR6 is required for IL-23–induced psoriasis-like inflammation in mice. ?J. Clin. Invest.2009,119:2 317–2 329?.? 12. Pierre Miossec, M.D., Ph.D., Thomas Korn, M.D., and Vijay K. Kuchroo, Ph.D. Interleukin-17 and Type 17 Helper T Cells. N Engl J Med 2009;361:888-98. 13. Honglin Wang,Thorsten Peters, Anca Sindrilaru, et al. TGF-β–dependent suppressive function of Tregs requires wild-type levels of CD18 in a mouse model of psoriasis. ?J. Clin. Invest.?2008,118:2 629–2 639?. 14. Amanda S. Büchau , Richard L. Gallo. Innate Immunity and antimicrobial defense systems in psoriasis. Clin Dermatol. 2007 ,25(6): 616–624. 15. Gerald G. Krueger, Richard G. Langley, Craig Leonardi,et al.A Human Interleukin-12/23 Monoclonal Antibody for the Treatment of Psoriasis. N Engl J Med 2007,356:580-592. 16. Aldona Pietrzak, Konrad Janowski,Gra�B zyna Chodorowska, et al. Plasma Interleukin-18 and Dendritic Cells in Males with Psoriasis Vulgaris. Mediators In?amm, 2007,2007:61254. 17. Lee E,Trepicchio WL,Oestreicher JL,et al.Increased Expression of Interleukin 23 P19 and P40 in Lesional Skin of Patients with Psoriasis Vulgaris.J Exp Med,2004,199:125-130. 18. Hak-Ling Ma, Spencer Liang, Jing Li, et al. IL-22 is required for Th17 cell–mediated pathology in a mouse model of psoriasis-like skin inflammation. ?J. Clin. Invest.?2008,118:597–607. 19. Proton Rahman,Tara Snelgrove,Lynette Peddle,et al.A variant of the IL4 I50V single-nucleotide polymorphism is associated with erosive joint disease in psoriatic arthritis.Arthritis Rheum. 2008,58(7)2207-2208. 20. James T Elder. IL-15 and Psoriasis: Another Genetic Link to Th17? J Invest Dermatol,2007,127:2 495–2 497.