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Melanoma is an aggressive skin tumor with upregulated expression of nuclear factor ��NF��-κB. Abnormal NF-κB signaling pathway takes part in angiogenesis in, proliferation, apoptosis, metastasis and other pathological physiological processes of melanoma, leads to abnormal expression of genes��and accelerates the progression of disorders. It has been demonstrated that NF-κB signal transduction pathway, key regulatory factors such as TNFR/TRADD/TRAF, TRAIL/TRAILR, FasR/FasL/FAP-1, gene mutation, etc, play important roles in the initiation and progression of melanoma. Therefore, studies on NF-κB signaling pathway may offer new ideas and methods for the treatment of melanoma.