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Seborrheic dermatitis is a common inflammatory skin condition characterized by erythema, scaling and pruritus with a predilection for areas rich in sebaceous glands. It affects patients' quality of life to an extent. Since it is a chronic and recurrent disease, there is a strong need for safe alternatives for its long-term management. In the past, antifungals, topical corticosteroids and keratolytics were the mainstay of its therapy. Now topical calcineurin inhibitors provide a safe alternative treatment for it. It has been demonstrated that such calcineurin inhibitors as pimecrolimus and tacrolimus are effective and safe in the treatment of facial seborrheic dermatitis.