1. �㽭��ҽҩ��ѧ���������е�������ҽԺ
2. �����е�������ҽԺƤ����

������һ�������ϸ��ȱʧ�йص�ɫ����ʧ��Ƥ�������������Σ���������β�λ�������촽����ֳ����ͷƤ����������ϥ������֫��������׵���Ч����ͽ����������β�λ����Ч�Ʒ�����ҩ������ֲ�������Ƽ������Ʒ��Ƚ��и������������β�λ���ٴ��ص㣬ѡ�ú�������Ʒ�������������β�λ����Ч��ָ���ٴ����ơ�

Vitiligo is a depigmentary skin disorder characterized by a chronic and progressive loss of melanocytes��MC��. It is easy to diagnose, but difficult to treat. Certain areas such as the lips, genitals, scalp, eyelids, elbows and knees, extremities, palms and soles are considered as difficult-to-treat areas. This paper describes the latest progress in effective therapies of vitiligo on difficult-to-treat sites, including medicine, surgical transplant, phototherapy and combination treatments. To choose a reasonable treatment strategy based on the characteristic of lesional sites may improve the clinical efficacy of vitiligo treatment.