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| PubMed | |
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Article by Cheng,f |
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Article by Li,X.J |
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Article by Chen,y |
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Article by Xun,J.P |
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Methods for studying in vivo dermatopharmacokinetics
In vivo dermopharmacokinetic research can directly disclose the action intensity, dose-effect relationship, and metabolic rhythm of topical and systemic drugs in target sites, which will contribute to the scheduling of reasonable dosage and dosing interval and provide a basis for rational application of drugs. The methods for in vivo dermopharmacokinetic research include tape stripping, dermal microdialysis, suction blistering, biopsy, agar gel disc test, spectroscopic analysis, etc.