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A case of acute myeloid leukemia cutis was reported. A 38?۲year?۲old man presented with 1?۲year history of confirmed acute granulocytic leukemia and 1?۲month history of skin eruptions on the trunk. Der?۲matological examination revealed dozens of erythematous, raised, infiltrated, painless nodules and plaques measuring 1-2 cm in diameter scattered on the trunk and right forehead. Bone marrow and immunological examinations confirmed the diagnosis of acute granulocytic leukemia ��M2��; one year after the confirmation of diagnosis, discrete papules and nodules developed on the trunk and forehead, histopathological and immunohistochemical examination confirmed the diagnosis of leukemia cutis. Multiple infiltration in skin, lung, spleen, kidney and lumbosacral vertebrae within a short period usually predicts a rapid progression and poor prognosis.