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A 54?۲year?۲old woman was hospitalized for a 2?۲year history of recurrent xerophthalmia and 2?۲month history of blisters on the trunk and limbs as well as oral ulcer. Physical examination revealed ulceration and hyperemia of nasal mucosa with crusts, large and shallow ulcer in oral cavity covered with edematous and white surface layer and surrounded by congestive margin, small scattered ulcers on the lower lip, edematous buccal mucosa with ulcers which were similar to the lesions on the dorsum of tongue. There were small number of tense blisters with thin wall scattered around or over the erythema in shoulders, neck, and trunk; Nikolsky sign was absent. This case was characterized by mucosal lesions, which were similar to the manifestation of ci?۲catricial pemphigoid; further, cutaneous and mucosal eruptions in this case varied with the progression of con?۲current tumors. Hence, it was liable to be misdiagnosed. Epidermolysis bullosa acquisita is correlated with type VII collagen. In some situations, the disorder may be linked to maligant tumors such as squamous cell carcino?۲ma.