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| PubMed | |
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Article by Yao,l |
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Article by He,l |
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Histological changes of photoaged skin
Photoaging of human skin is a continuous process induced by chronic exposure to sun light, especially ultraviolet rays. Histologically, photoaged skin is characterized by elastosis, collagen decrease and alterations in epidermal keratinocytes, melanocytes and Langerhans cells. The mechanism of skin photoaging is mainly related to immune system, cytokine change, increase in the production of matrix metalloproteinase and active oxygen, DNA damage, etc. This review presents histological changes of photoaged skin and their mecha?۲nism.