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The barrier function of epidermis is maintained via continuous renewal and repair. Ion channels can influence the speed of barrier repair via modulating intracellular and extracellular ion concentra-tion of keratinocytes. Related ion channels include voltage-gated calcium channel, voltage-gated magnesium channel, voltage-gated sodium channel, ligand-gated chloride channel, and ligand-gated non-selective cation channel. P2X receptor, TRPV receptor, glutamate receptor and nicotinic acetylcholine receptor all belong to ligand-gated non-selective cation channel. Ion channels affect barrier repair by either direct or indirect media-tion of signal transduction via neurotransmitters and G protein-coupled receptors.