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Plasma is the fourth state of matter. Plasma skin regeneration (PSR), as a novel method for resurfacing that uses plasma energy to create a thermal effect on skin, is chromophore independent and does not vaporize tissue. PSR has been used for the treatment of rhytides, dyschromias, photoaging, skin laxity, acne scars and other skin conditions. The safety profile of PSR is excellent. Several treatment protocols with variable energy settings allow for individualized treatment and offer fine control over injury degree and recovery time.