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Photoaging is mainly characterized by rhytides, telangiectacia, dyschromia, hyperkeratosi, etc. Fractional photothermolysis has created a therapeutic option for these medically recalcitrant conditions. The technology is classified into two kinds, i.e., nonablative fractional laser and ablative fractional laser, and the latter mainly includes fractional CO2 laser and fractional erbium laser. This article describes the clinical application and side effects of, as well as histology changes after irradiation with the above lasers.