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As a group of idiopathic diseases of unknown origin, hypereosinophilic syndrome is characterized by eosinophilia in bone marrow, peripheral blood and tissue usually with multiple-organ involvement. Eosinophilia dermatitis is specifically referred to eosinophilia in skin tissue. Conventional therapies like corticosteroids, hydroxyurea and cyclosporins are nonspecific and carry many side effects in the long run. Recently, it has been evidenced that hypereosinophilic syndrome is associated with fusion genes in eosinophils and abnormal T cell clones�� and��tyrosine kinease inhibitors, interferon-α and anti-interleukin-5 monoclonal antibodies have specific efficacy for this disease.