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PI3K/Akt/mTOR�ź�ת��ͨ·�Ǵٴ��ͨ·���ںܶ�����������Լ����ͨ·����Ļ������������ƻ���PTEN����ȱʧ��PI3K������ͻ�䡢Akt������ͻ�䡣�����о����֣���ͨ·ʧ���ɴٽ�����ϸ���Ĵ����������������Ƥ������������������Ҫ�����ã��Ѿ��������Ƹ�ͨ·�е��źŷ��ӿ������ƶ���������Ŀǰ����Ը�ͨ·������ҩ��Ҳ���о��У���Ҫ������mTOR���Ƽ���

The PI3K/Akt/mTOR pathway is a prototypic survival pathway that is constitutively activated in various types of cancer. This pathway may be activated by function loss of tumor suppressor gene PTEN, amplification or mutation of PI3K and Akt genes. Recent studies have shown that the abnormality of PI3K/Akt/mTOR pathway may promote the survival and development of tumor cells, and continuous activation of this pathway is associated with the development of cutaneous tumors. It has been found that many tumors can be treated by inhibition of this pathway. Multiple inhibitors of this pathway have been developed and are being evaluated in laboratory and clinical trials, with much attention focused on mTOR inhibition.

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