����ҽѧԺ�ڶ�����ҽԺ

1��75���л��ߣ����ɡ���֫���������Ժ�ߡ��߿��̦޺��Ƥ��5�ꡣƤ���Ƽ�飺���������ɺ���֫�������졢�Һ�ɫ�����԰�Ƭ�Ͱ߿飬�Ա���Ϊ����ȫ��dz���ܰͽ����״�δ����ϵͳ�����������֯������ʾ����Ƥ����������������ʺ񣬱�Ƥ�ڿɼ�����Ⱦ�������ܰ�ϸ�������γ�Pautrier΢ŧ�ס���Ƥdz����Ƭ״���ſ�״�ܰ���ϸ������ϸ���������ԡ������黯��ǣ�����ϸ��CD3��CD8��GrB��LCA��TIA-1���ԣ�CD4��CD5���ԡ�����ԭ����Ƥ��CD8+�ױ�Ƥ��Tϸ���ܰ�����ϡ��ڷ�ά�������Ʋ���������ת��

A 75-year-old man presented with a 5-year history of pruritic erythema, plaque and lichenification distributed on the trunk and extremities. Physical examination showed diffusely dark-red and gray-black infiltrative erythema and plaque on the neck, trunk and extremities, especially on the upper back. No superficial lymphadenectasis or definite evidence of systemic involvement was observed. Histopathology of biopsy specimens revealed an irregular epidermal hyperplasia, acanthosis, dense and massive infiltrations of the upper dermis by and atypical lymphoidocytes with hyperchromatic nuclei which formed Pautrier microabcesses. There was patchy and lump-like lymphoid infiltration with atypical cells in the superficial dermis. Tumor cells were positive for CD3, CD8, granzyme B ��GrB��, LCA and TIA-1, but negative for CD4 and CD5. A diagnosis of primary cutaneous CD8-positive epidermotropic T-cell lymphoma was made. Oral viaminate was effective in controlling the condition.

��