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Drug-induced lupus erythematosus ��DILE�� is an autoimmune disease induced by different drugs. At present, more than 80 drugs have been shown to be associated with this disease. It is characterized by arthralgia, myalgia, fever and serological abnormity ��such as antinuclear antibody and antihistone antibodies��. After discontinuation of associated drugs, clinical symptoms can be improved promptly, but laboratory abnormality may persist for a long time. To study about DILE is not only helpful to reveal the pathogenesis of SLE but also beneficial to the reasonable prevention and treatment of SLE.