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Both Stevens-Johnson syndrome ��SJS�� and toxic epidermal necrolysis ��TEN�� belong to severe bullous drug eruptions. Both of them are clinically characterized by extensive epidermal necrosis and exfoliation, and histologically characterized by generalized apoptosis of keratinocytes, a process that results in the separation of epidermis from dermis. There is evidence that keratinocyte apoptosis is mainly ascribed to perforin/granzyme B and Fas/FasL. Besides supportive treatment, the application of multiple antiapoptotic agents could be of potential benefit to the management of severe bullous drug eruptions. This article presents the antiapoptotic therapy of severe bullous drug eruptions.