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Contact urticaria refers to a wheal��itching and flare reaction following external contact with an allergen. According to the pathogenesis of contact urticaria, it can be described in three categories: non-immunological contact urticaria, immunological contact urticaria and undetermined contact urticaria. Non-immunological contact urticaria is typically characterized by local eruptions at the site of exposure that can disappear within several hours. Meanwhile, immunological contact urticaria is manifested not only as local skin lesions but also as the involvement of respiratory system, alimentary system, etc. Since the etiology of contact urticaria is complicated, etiological treatment is difficult, whereas specific immunotherapy and anti-IgE monoclonal antibody might benefit its treatment.