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Regulatory T cells are a hotspot in medical domain nowadays. Human naturally occurring regulatory T cells (nTregs), derived from the thymus, play a critical role in the suppression of autoimmunity. Recent studies have suggested that there is a strong correlation between nTregs and tumor progression. The proliferation, aggregation, and transmigration towards tumor cells, of nTregs, all contribute to the escape of immune effector cells from antitumor immunity. However, the relationship between nTregs and prognosis of tumors is unclear. Further studies are required for the development of more effective drug targets and new therapy.